Targeting prostate tumors with nanoworms

By Heather Buschman, Ph.D.
July 6, 2010
6

One way to inhibit a tumor’s growth is to choke off its blood supply. The trick is to create a clot that specifically blocks flow to the tumor without harming other parts of the body. To accomplish this, a research team led by Dr. Erkki Ruoslahti, distinguished professor at Sanford-Burnham, coated nanoparticles with two different homing signals that specifically direct them to proteins on tumor blood vessels. One signal was generated by a string of just five amino acids (the molecular subunits that make up a protein), while the other consisted of six amino acids. These two types of targeted nanoparticles worked cooperatively to induce blood clots, and an elongated version of these particles, called “nanoworms,” did an even better job of it. As the nanoworms induced clotting, more and more binding sites appeared, attracting more nanoworms and further enhancing the blockage.

In a study published June 29, 2010 in the journal Blood, the researchers used the targeted nanoworms to treat a mouse model of human prostate cancer. The nanoworms triggered widespread clotting in the prostate tumor vessels, but left normal tissues alone. As a result, the cancer cells starved and the tumors shrank.

“The nanoparticle combination we used gives a dramatic reduction in tumor growth, and there is no drug involved,” explained Dr. Ruoslahti. “Next, we’ll add a drug to one or both of the nanoparticles to further boost the efficacy, hopefully to a point where we can cure the mice of their tumors.”

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Heather Buschman, Ph.D.

Heather was an SBP Communications staff member.

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6 Comments

  1. Can you please explain the efficacy of your worms as compared to Avastin. As we all know, Avastin stops angiogenisis. How does this differ from your research. Also, how do you relate to Provenge?

    • This research is at the very earliest stages, so there has been no comparative efficacy testing yet. However, Dr. Ruoslahti’s research highlights a new approach against prostate cancer that may have great potential. Much more work to be done.

  2. Pingback: The Beaker — Sanford-Burnham’s Medical Research Blog « NCTimes.com Blogs

  3. Pingback: Center for Nanomedicine » Dr. Erkki Ruoslahti’s Laboratory Discovers New Cancer Treatment Approach

  4. “As the nanoworms induced clotting, more and more binding sites appeared, attracting more nanoworms and further enhancing the blockage”.
    Would they do the cancers cure and cause the death by general thrombosis (statistic for cancers would be better)?

  5. Constance Moni on

    technology just keeps getting better but weither or not it will be 100% effective is a question that is to be answered…#random

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